Penicillin Sodium for Injection

  • Main ingredients
  • Strength
  • Package



White crystalline powder.




It can be used to following infections induced by susceptible bacteria, such as abscess, bacteremia, pneumonia, and endocarditis.

Penicillin is the first choice drug for the following infections:

1. Infections by hemolytic streptococcus, such as pharyngitis, amygdalitis, scarlatina, erysipelas, cellulitis, puerperalism.

2. Streptococcus pneumoniae infections, such as pneumonia, otitis media, meningitis, bacteremia.

3.  Staphylococcus which doesn’t produce penicillinase.

4.  Anthrax.

5.  Clostridium difficile infections, such as tetanus, gas gangrene.

6.  Syphilis

7. Leptospirosis

8. Relapsing fever

9. Diphtheria

10.Penicillin combines aminoglycosides to treat endocarditis induced by Streptococcus viridans.


Penicillin also can be used to treat:

1. Epidemic cerebrospinal meningitis.

2. Actinomycosis

3. Gonorrhea

4. Vincents angina

5. Lyme disease

6. Rat-bite fever

7. Infections by Listeria monocytogenes

8. Infections by anaerobes except bacteriodes fragilis.


Before the patients who have rheumatic or congenital heart disease start to perform stomatological, dental, gastrointestinal or genitourinary tract operations, penicillin can be used to prevent infectious endocarditis.


Usage and Dosage


Intramuscular injection or Intravenous drip.

1.     Adults: IM injection, 800,000-2,000,000 units daily, divided in 3-4 times; IV drip, 2,000,00020,000,000 units, divided into 2-4 times.

2.     Children: IM injection, 25,000 units/kg body weight, once every 12hours; IV drip, 50,000200,000 units/kg body weight daily, divided into 2-4 times.

3.     Newborns: 50,000 units/kg body weight each time, IM or IV drip; first week of born, once every 12 hours, over one week patients, once every 8 hours, severe infectious patients, once every 6 hours.

4.     Premature infant: 30,000 units/kg body weight each time, once every 12 hours in the first week of born, once every 8 hours for 2-4 weeks infants; once every 6 hours after that.

5.     Patients with renal function impairment: the patients of light and moderate renal function impairment don’t need to reduce the dose, the patients with severe renal function impairment should extend the administration interval or reduce the dose. When the endogenous creatinine clearance rate is 10-50 ml/min, extend the administration duration from 8hours to 8-12 hours or the administration interval remains the same but reduce the dose by 25%; when the endogenous creatinine clearance rate is less than 10ml/min, extend the administration interval to 12-18 hours or reduce the dose to 25-50% of the normal dose and the administration interval remains still.

6.     IM injection, dissolve 500,000 units penicillin sodium into 1 ml sterile water for injection, if over 500,000 units, add 2ml sterile water for injection. The solvent can’t be sodium chloride injection; if IV drip, the administration speed should be not more than 500,000 units per minute, to avoid the toxicity reaction of the central nervous system.




2.4 g, calculated on C16H17N2NaO4S, 4,000,000 units.




Keep in well-closed container, in a dry place.




10vials/box, 50vials/box, mould vials for antibiotics.


Shelf life


24 Months