【Trade name】

Shazhi

【Description】

 Capsule with white powder content.

【Indications】

For the treatment of HIV (human immunodeficiency virus) infection in combination therapy.

【Usage and Dosage】

The interval of dosing is 12 hours, which is not related with meal.

For adult with bodyweight≥60 kg, 40 mg per time, 2 times a day; for the adult with bodyweight＜60 kg, 30mg per time, 2 times a day.

For the child with bodyweight＜30 kg, 1mg per kg per time, 2 times a day; for the child with bodyweight≥30 kg, equal to the adult.

Dose Adjustment: If the patients have hand, foot numbness, tingling after taking the drug, attention should be paid to peripheral neuropathy. These symptoms can hardly be found in children. If any of these symptoms appear in the treatment, the stavudine treatment should be immediately terminated and symptoms can disappear, however, in some cases, the symptoms will aggravate. Until the symptoms disappeared completely, the adults could continue using the drug as the following dosages:

Weight≥60 kg, 20mg/time and twice a day;

Weight<60 kg, 15mg/time and twice a day.

The children dosage will be half.

If neuropathy occurs after continuing using this product, the treatment should be stopped.

Renal insufficiency: see Table III for the dosage of renal dysfunction.

【Specification】

(1) 15mg; (2) 20mg

【Storage】

Preserve in a tightly sealed container, stored at a dry place, protected from light.

【Package】

Pharmaceutical plastic bottle packaging, 15 mg x 60 capsules/bottle, 20 mg x 60 capsules/bottle.

【Shelf life】

Tentative 18 months